Saturday, April 18, 2015

The 8 most fascinating concepts in microbiology

Last year I had spare moments and wanted to learn something new. Hence I set out to familiarize myself with the full details of the cells' inner nature. After all, cells are small and undoubtedly without much room for complexities. As false as this assumption was - it got me engaged in a wonderful journey of learning and revelation.
After having been reading about microbiology for a while I have realized that most of this small scale natural wonder is amazing - while a few things are mind blowing.
Below are the topics I found most fascinating. NB: use with caution - my interpretation might be wrong or misleading.
Proteins, particularly enzymes, does their job propelled mostly by the vibrational force of ambient heat. As their molecules twists and wiggles, they grab their prey and mercilessly act upon them.
Viruses reproduce in host cells. Viruses break into cells, in various ways, and hijacks the cells DNA / RNA production line. When the needed components are reproduced, the virus self-assemble and blows up it's host.
Nerve cells are chemical-electrical. Various kinds of external stimuli, such as stretching, charges or chemicals cause the nerve cells to open it's membranes and absorb ions. This inflow charges the cells and a pulse is generated, traveling their long tails.
Nerve cells can be extremely long. Their signal conveying tails, axons, can reach from your toe to the spinal cord.
Cell membranes are self organizing. The molecules of the cell membrane, lipids, are naturally drawn into spherical shields - due to their hate of water and deep love of their own kinds. Given the right temperature, and some cholestrole, the resulting membranes are even liquid - a perfect home for cells.
Gene regulation allows genetic meta programming. By producing gene blocking proteins, the cells can block certain features of it's own DNA. When these blocking mechanism blocks other blockers - or responds to external signalling - we have a highly flexible, and highly complex, mechanism.
Visual and auditory inputs are passed through fast and slow neural pathways for time shift comparison. The brain receive both real-time and delayed visual input, which when compared can be used to detect motion in the visual scene. This simple mechanism allows seeing organisms to draw attention to important matters, such as a an attacker or prey, or annoyances such as a blinking commercial. The right and left ears' frequency signals are similarly shifted - to detect phase shifts revealing the source's angle to the head.
Some cells, mostly bacteria, exchanges genes to speed up evolution.Called horizontal gene transfer it must be highly useful when someone hatches a trick for synthesizing a useful molecule or for avoiding threats - such as antibiotics. Multiple mechanisms exists, one is a simple tube from one bacteria to another, one uses viruses for delivery.
Recommended reads:
  • Wagner - The arrival of the fittest
  • Groh - Making space, how the brain knows where we are
  • Lots of people - Essential Cell Biology

Sunday, January 4, 2015

Commission a drone swarm!

Online shopping promises effortless purchases from your own coach - without the hassles of entering a store and searching the shelves.  But when the goods are purchased, something nasty awaits - literally.  We have to wait, often for several days, before the life improving package arrives.
Drones are suggested as a solution to this, most famously by Amazon’s leading star, Jeff Bezos. They are working with an idea where warehouses in big cities can send books fairly immediately to waiting customers using Amazon’s drones. Reducing the wait to something like an hour, depending on demand, they would be available around the clock.
Technical, regulatory and safety challenges must be resolved before these shipments can be witnessed in the sky, however it all looks feasible and I can’t wait.
This is all good and the future looks bright, but what would be the next step?  Amazon plans to invest in their own drone network and their delivery bots will only serve their owner.  Also, the drones will have to be tailored for their tasks and there will be a limit to how big things they can carry.
What if anyone could order a drone for their transport need, business or private?  What if they could be used to carry anything, anywhere?
To get there, I suggest the future brings us commissionable, stackable drones. These can be owned by anyone - like todays taxis - but accessible through a common central.  If big things are to be transported - the drones stack together and collectively take your shipment.  This can be done either using robot arms or just be flying in formation, eventually using some kind of standardization.  If packages are to travel further than the future’s batteries permits, which is far, one and one drone can be replaced in mid air - or the shipment can be re-droned at centrals.  The customer pays for the number of drones commissioned and perhaps the delivery speed.
When this system is in place it’s only natural that it’s extended to carry people, families and finally - birthday cakes.  That would be some future!